期刊
NANO LETTERS
卷 17, 期 11, 页码 6816-6821出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.7b03093
关键词
Nanoreactors; nanocontainers; energy regeneration; artificial organelle; hybrid materials; bottom-up
类别
资金
- Max Planck Society
- Federal Ministry of Education and Research (BMBF) of Germany
For energy supply to biomimetic constructs, a complex chemical energy-driven ATP-generating artificial system was built. The system was assembled with bottom-up detergent-mediated reconstitution of an ATP synthase and a terminal oxidase into two types of novel nanocontainers, built from either graft copolymer membranes or from hybrid graft copolymer/lipid membranes. The versatility and biocompatibility of the proposed nanocontainers was demonstrated through convenient system assembly and through high retained activity of both membrane-embedded enzymes. In the future, the nanocontainers might be used as a platform for the functional reconstitution of other complex membrane proteins and could considerably expedite the design of nanoreactors, biosensors, and artificial organelles.
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