期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 816, 期 -, 页码 32-37出版社
ELSEVIER
DOI: 10.1016/j.mrgentox.2017.02.005
关键词
Nanoparticles; Zinc oxide; Titanium dioxide; Genotoxicity; Antagonism
资金
- Rudolf-Bartling-Stiftung
Titanium dioxide nanoparticles (TiO2-NPs) and zinc oxide nanoparticles (ZnO-NPs) are often used in sunscreens and other consumer products due to their photoprotective properties. However, concern exists regarding them possibly causing cyto- and genotoxic effects. The aim of this study was to assess cyto- and genotoxicity of these nanomaterials after single or combined exposure. For this purpose, a battery of cell culture test systems for human nasal mucosa (monolayer, air-liquid interface and mini organ culture) were exposed to 0.1-20 mu g/ml of TiO2- and ZnO-NPs alone and in combination. Cytotoxicity was measured by the MIT assay, and DNA damage and repair capacity were investigated using the comet assay. TiO2-NPs did not exhibit any cyto- or genotoxic potential within the tested concentrations. However, results of the study indicated cyto- and genotoxicity resulting from ZnO-NPs. The genotoxicity could be antagonized by TiO2-NPs. Furthermore, the DNA repair capacity after ZnO-NP-induced DNA damage was enhanced by TiO2-NPs. The adsorption of dissolved zinc ions onto TiO2-NPs is discussed as the major antagonistic mechanism. The combination of both metal oxide nanoparticles interferes with the genotoxicity of ZnO-NPs and should be discussed as a reasonable and safe alternative to the sole use of ZnO-NPs in consumer products. (C) 2017 Elsevier B.V. All rights reserved.
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