期刊
MUSCLE & NERVE
卷 57, 期 1, 页码 E52-E59出版社
WILEY
DOI: 10.1002/mus.25711
关键词
denervation; motor unit; myofiber type grouping; myofiber switching; reinnervation
资金
- National Institutes of Health [R01AG017896, T32HD071866, P2CHD086851, R01AG046920, R01HD084124, UL1TR001417]
Introduction: Myofiber type grouping is a histological hallmark of age-related motor unit remodeling. Despite the accepted concept that denervation-reinnervation events lead to myofiber type grouping, the completeness of those conversions remains unknown. Methods: Type I myofiber grouping was assessed in vastus lateralis biopsies from Young (26 +/- 4 years; n=27) and Older (66 +/- 4 years; n=91) adults. Grouped and ungrouped type I myofibers were evaluated for phenotypic differences. Results: Higher type I grouping in Older versus Young was driven by more myofibers per group (i.e., larger group size) (P<0.05). In Older only, grouped type I myofibers displayed larger cross-sectional area, more myonuclei, lower capillary supply, and more sarco(endo) plasmic reticulum calcium ATPase I (SERCA I) expression (P<0.05) than ungrouped type I myofibers. Discussion: Grouped type I myofibers retain type II characteristics suggesting that conversion during denervation-reinnervation events is either progressive or incomplete.
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