期刊
MUSCLE & NERVE
卷 57, 期 1, 页码 136-139出版社
WILEY
DOI: 10.1002/mus.25700
关键词
3,4-diaminopyridine; coverage probability; Lambert-Eaton myasthenia; outcome measures; reliability; timed up-and-go test
资金
- National Center for Advancing Translational Sciences, National Institutes of Health [UL1TR001117]
- National Institute of Neurological Disorders and Stroke, National Institutes of Health [K23NS085049]
- Jacobus Pharmaceutical Co (JPC)
Introduction: We report the reliability of a new measure, the triple-timed up-and-go (3TUG) test, for assessing clinical function in patients with Lambert-Eaton myasthenia (LEM). Methods: Intrarater reproducibility and interrater agreement of the 3TUG test were assessed in 25 control participants, 24 patients with non-LEM neuromuscular disease, and 12 patients with LEM. The coverage probability (CP) method was the primary measure of reproducibility and agreement. The a priori acceptable range was< 20% difference in 3TUG test times and a CP >= 0.90 confirmed agreement. Results: CP values> 0.90 for intrarater and interrater tests confirmed acceptable reproducibility and agreement for all groups. Discussion: The 3TUG test is a quick, noninvasive, and reproducible measure that is easy to perform, measures clinically important weakness in LEM patients, and requires little training. Additional evaluation in a larger number of LEM patients is in progress to validate the 3TUG test as a clinical measure in LEM.
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