期刊
MATERIALS TODAY-PROCEEDINGS
卷 5, 期 -, 页码 S172-S179出版社
ELSEVIER
DOI: 10.1016/j.matpr.2018.08.062
关键词
Nanoemulsion; PIC Method; palm kernel oil esters; ibuprofen
资金
- Malaysian Ministry of Education (MOE)
- Universiti Putra Malaysia (UPM) through the Fundamental Research Grant Scheme (FRGS) [5524939]
- Universiti Putra Malaysia (UPM) through the Putra Grant IPM [9456200]
- MINECO [CTQ2011-29336-CO3]
- Generalitat de Catalunya [2009-SGR-961]
- CIBER-BBN
This study reports the formation of nanoemulsions from palm-kernel oil esters (PKOE)/Cremophor EL/water systems intended for topical administration of a non-steroidal anti-inflammatory drug, ibuprofen. Nanoemulsions containing 2% ibuprofen, various oil:surfactant ratios (10:90, 20:80 and 30:70) and 80% of water were selected from the ternary system of PKOE/Cremophor EL/water and prepared by the phase inversion composition (PIC) method. The characterization of the nanoemulsions such as droplet size, polydispersity index, zeta potential, stability and the permeation of ibuprofen from nanoemulsions were evaluated.. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. (C) 2018 The Author(s). Published by Elsevier Ltd.
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