4.3 Article

Proteomic Analysis of the Human Anterior Pituitary Gland

期刊

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
卷 22, 期 12, 页码 759-769

出版社

MARY ANN LIEBERT, INC
DOI: 10.1089/omi.2018.0160

关键词

proteomics; anterior pituitary; diagnostics; biomarkers; ophthalmology; endocrinology

资金

  1. research grant DBT Programme Support on Neuroproteomics of Neurological Disorders''
  2. DBT, Government of India [BT/01/COE/08/05]
  3. Johns Hopkins University
  4. National Institute of Neurological Disorders and Stroke (NINDS) [1RO1NS055628-01A2]
  5. Council for Scientific and Industrial Research (CSIR), Government of India
  6. MRC [MR/M018539/1] Funding Source: UKRI

向作者/读者索取更多资源

The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.

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