期刊
MOVEMENT DISORDERS
卷 33, 期 1, 页码 159-164出版社
WILEY
DOI: 10.1002/mds.27215
关键词
Parkinson's disease; deep brain stimulation; directional leads; local field potentials; DBS programming
资金
- Rosetrees Trust
- National Institute of Health Research Oxford Biomedical Research Center
- European Academy of Neurology (EAN)
- Medical Research Council [MC_UU_12024/1, MR/N003446/1]
- Medical Research Council [MR/P012272/1, MR/N003446/2] Funding Source: researchfish
- Rosetrees Trust [M235-CD1, M235-CD3, M526-B-CD1] Funding Source: researchfish
- MRC [MR/N003446/2, MC_UU_12024/1, MR/P012272/1, MR/N003446/1] Funding Source: UKRI
Background: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming. Objectives: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD. Methods: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months. Results: Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. (c) 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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