期刊
PHYSICAL BIOLOGY
卷 16, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1478-3975/aaee45
关键词
spindle positioning; cyst formation; early cleavage; phase field; multicellular system; numerical simulation
资金
- JSPS KAKENHI [15H05857, 16K05523]
- Grants-in-Aid for Scientific Research [15H05857, 16K05523] Funding Source: KAKEN
A method of numerical simulation of cell division using phase fields is presented. The cell division plane is obtained as a result of the spindle position and orientation considered with the spatial distribution of the activated cortical force generators and the dividing cell shape. To exemplify the application of the proposed method, numerical simulations of the development of cysts and early embryos are performed. The numerical results demonstrate that the activated cortical force generators that are localized at the lateral cortices of the epithelial cells lead to the formation of a single central lumen. It is additionally shown that the linear distribution of the activated cortical force generators along the animal-vegetal axis of a spherical cell engenders a similar cell proliferation of the divided embryo generated by the 32 cell period in a sea cucumber.
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