期刊
MOLECULES
卷 22, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules22040578
关键词
Na/K-ATPase; non-small cell lung cancer; cardiotonic steroids; apoptosis; autophagy
资金
- Universidade Federal Fluminense (FOPESQ/UFF)
- FIOCRUZ
- CNPq
- FAPERJ
- Programa de Produtividade Cientifica da Universidade Estacio de Sa
Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.
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