4.6 Review

Current Development Status of MEK Inhibitors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs

Ryan H. Takahashi et al.

XENOBIOTICA (2017)

Review Chemistry, Medicinal

MEK inhibitors in oncology: a patent review (2015-Present)

Debarshi Kar Mahapatra et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2017)

Meeting Abstract Oncology

Atezolizumab (A) plus cobimetinib (C) in metastatic melanoma (mel): Updated safety and clinical activity.

Wilson H. Miller et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Review Dermatology

MEK Inhibitors in the Treatment of Metastatic Melanoma and Solid Tumors

Antonio M. Grimaldi et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2017)

Review Oncology

Emerging therapeutic agents for lung cancer

Bhagirathbhai Dholaria et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)

Meeting Abstract Oncology

Clinical activity and safety of cobimetinib (cobi) and atezolizumab in colorectal cancer (CRC).

Johanna C. Bendell et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Review Oncology

Novel melanoma therapy

Eddy C. Hsueh et al.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2016)

Review Oncology

Combined BRAF and MEK inhibition for the treatment of BRAF-mutated metastatic melanoma

Paola Queirolo et al.

CANCER TREATMENT REVIEWS (2015)

Article Pharmacology & Pharmacy

MEK inhibitors beyond monotherapy: current and future development

Ian E. Templeton et al.

CURRENT OPINION IN PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

BRAF and MEK inhibition for the treatment of advanced BRAF mutant melanoma

Juliet Richman et al.

EXPERT OPINION ON PHARMACOTHERAPY (2015)

Editorial Material Oncology

Nivolumab plus ipilimumab in the treatment of advanced melanoma

Katy K. Tsai et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)

Article Oncology

Dabrafenib and Trametinib, Alone and in Combination for BRAF-Mutant Metastatic Melanoma

Alexander M. Menzies et al.

CLINICAL CANCER RESEARCH (2014)

Review Pharmacology & Pharmacy

Prospects for MEK inhibitors for treating cancer

Juan Martin-Liberal et al.

EXPERT OPINION ON DRUG SAFETY (2014)

Review Pharmacology & Pharmacy

BRAF inhibitors in cancer therapy

Carolina Hertzman Johansson et al.

PHARMACOLOGY & THERAPEUTICS (2014)

Review Pharmacology & Pharmacy

MEK in cancer and cancer therapy

Cindy Neuzillet et al.

PHARMACOLOGY & THERAPEUTICS (2014)

Article Multidisciplinary Sciences

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou et al.

NATURE (2013)

Article Radiology, Nuclear Medicine & Medical Imaging

Differences in the Biologic Activity of 2 Novel MEK Inhibitors Revealed by 18F-FDG PET: Analysis of Imaging Data from 2 Phase I Trials

Francoise Kraeber-Bodere et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

Article Chemistry, Medicinal

Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

Kenneth D. Rice et al.

ACS MEDICINAL CHEMISTRY LETTERS (2012)

Article Chemistry, Medicinal

Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer

Qing Dong et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Chemistry, Medicinal

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent

Yoshiaki Isshiki et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Chemistry, Medicinal

Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)

Hiroyuki Abe et al.

ACS MEDICINAL CHEMISTRY LETTERS (2011)

Review Pharmacology & Pharmacy

Targeting the MAPK pathway in melanoma: Why some approaches succeed and other fail

Gajanan S. Inamdar et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Review Pharmacology & Pharmacy

Emerging MEK inhibitors

James A. McCubrey et al.

EXPERT OPINION ON EMERGING DRUGS (2010)

Article Chemistry, Medicinal

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Review Chemistry, Medicinal

Putative allosteric MEK1 and MEK2 inhibitors

Steve Price

EXPERT OPINION ON THERAPEUTIC PATENTS (2008)

Review Biochemistry & Molecular Biology

Clinical experience of MEK inhibitors in cancer therapy

Ding Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Article Chemistry, Medicinal

Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors

SL Han et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Pharmacology & Pharmacy

Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery

N Thompson et al.

CURRENT OPINION IN PHARMACOLOGY (2005)

Article Chemistry, Multidisciplinary

In vitro and in vivo metabolism of the anti-cancer agent CI-1040, a MEK inhibitor, in rat, monkey, and human

PA Wabnitz et al.

PHARMACEUTICAL RESEARCH (2004)

Review Cell Biology

The ups and downs of MEK kinase interactions

C Hagemann et al.

CELLULAR SIGNALLING (2001)

Article Multidisciplinary Sciences

Mammalian MAP kinase signalling cascades

LF Chang et al.

NATURE (2001)