期刊
MOLECULES
卷 22, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules22030365
关键词
epilepsy; ABC transporters; oxidative stress; antiepileptic drugs; pharmacoresistance
资金
- Council of Scientific and Industrial Reserch (CSIR), Govt. of India
- DBT, Govt. of India
- CSIR [BSC0123]
Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response.
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