期刊
MOLECULES
卷 22, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules22030461
关键词
pyrroles; pyrrolopyridines; synthesis; anti-inflammatory assay; cytokine inhibitors; docking study
资金
- Pharmaceutical Organic Chemistry
- Faculty of Pharmacy, Helwan University
A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, H-1-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据