期刊
MOLECULES
卷 22, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules22020302
关键词
oxidation; porphyrinatoMn(III); hydrogen peroxide; arylthio; cyclohexylthio-lapachones; sulfonyl-lapachones; polyvinylpyrrolidone; antibacterial activity
资金
- CNPq
- CAPES
- FAPERJ
- PRONEX-FAPERJ [E-26/110.574/2010]
- FCT (Portugal)
- European Union
- QREN
- FEDER
- COMPETE [PEstC/QUI/UI0062/2011]
- CESAM [FCT UID/MAR/0017/2013]
- National NMR Network
- QREN [FCOMP-01-0124-FEDER-010840, PTDC/QUI-QUI/102454/2008]
- CAPES [7129/13-0]
- FCT [SFRH/BPD/79521/2011]
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones 4b-g and of the sulfonyl-lapachones 7e and 7g reduced the growth of S. aureus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据