期刊
MOLECULES
卷 22, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules22122092
关键词
biotoxicity; biodegradation; cytotoxicity; genotoxicity; hemocompatability; nonwoven fabrics; bone implant; poly(l-lactide-co-glycolide); synthetic poly([R; S]-3-hydroxybutyrate); encapsulated growth factor
资金
- Structural Founds in the frame of Biodegradable fibrous products project (acronym BIOGRATEX) [POIG01.03.01-00-07/08-09]
- Lodz University of Technology, Department of Material and Commodity Sciences and Textile Metrology, Poland
In response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants for osseous tissue regeneration made of a newly developed blend of poly(l-lactide-co-glycolide) (PLGA) and syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been developed and fabricated. Afibre-forming copolymer of glycolide and l-lactide (PLGA) was obtained by a unique method of synthesis carried out in blocksusing Zr(AcAc)(4) as an initiator. The prototypes of the implants are composed of three layers of PLGA or PLGA/PHB, nonwoven fabrics with a pore structure designed to provide the best conditions for the cell proliferation. The bioactivity of the proposed implants has been imparted by introducing a hydroxyapatite material and IGF1, a growth factor. The developed prototypes of implants have been subjected to a set of in vitro and in vivobiocompatibility tests: in vitro cytotoxic effect, in vitro genotoxicity and systemic toxicity. Rabbitsshowed no signs of negative reactionafter implantation of the experimental implant prototypes.
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