4.6 Review

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Alzheimer's disease as oligomeropathy

Kenjiro Ono

NEUROCHEMISTRY INTERNATIONAL (2018)

Review Medicine, Research & Experimental

Lessons Learned from Alzheimer Disease: Clinical Trials with Negative Outcomes

Jeffrey Cummings

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2018)

Review Biochemistry & Molecular Biology

The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

Lucas J. Sosa et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Editorial Material Multidisciplinary Sciences

Stop Alzheimer's before it starts

Eric McDade et al.

NATURE (2017)

Article Multidisciplinary Sciences

BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

Martin Weber et al.

SCIENTIFIC REPORTS (2017)

Review Neurosciences

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

Riqiang Yan

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Article Medical Laboratory Technology

Accuracy of cerebrospinal fluid Aβ1-42 measurements: evaluation of pre-analytical factors using a novel Elecsys immunosassay

Malgorzata Rozga et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2017)

Article Clinical Neurology

Decreased Plasma β-Amyloid in the Alzheimer's Disease APP A673T Variant Carriers

Henna Martiskainen et al.

ANNALS OF NEUROLOGY (2017)

Article Clinical Neurology

RESULTS FROM A FIRST-IN-HUMAN STUDY WITH THE BACE INHIBITOR CNP520

Mike Ufer et al.

Alzheimers & Dementia (2016)

Review Biochemistry & Molecular Biology

New Directions for Protease Inhibitors Directed Drug Discovery

Yoshio Hamada et al.

BIOPOLYMERS (2016)

Review Neurosciences

Post-translational regulation of the β-secretase BACE1

Wataru Araki

BRAIN RESEARCH BULLETIN (2016)

Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

Article Pharmacology & Pharmacy

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain

Kapil Gadkar et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

Article Biochemistry & Molecular Biology

Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System

Kathryn M. Munro et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2016)

Article Neurosciences

No diurnal variation of classical and candidate biomarkers of Alzheimer's disease in CSF

Claudia Cicognola et al.

MOLECULAR NEURODEGENERATION (2016)

Review Behavioral Sciences

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease

Riqiang Yan et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

Article Cell Biology

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

Deepak Kumar Vijaya Kumar et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Geriatrics & Gerontology

Mechanisms of Aβ Clearance and Degradation by Glial Cells

Miriam Ries et al.

FRONTIERS IN AGING NEUROSCIENCE (2016)

Review Neurosciences

Proteomic Substrate Identification for Membrane Proteases in the Brain

Stephan A. Mueller et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

Review Neurosciences

Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs

Riqiang Yan

TRANSLATIONAL NEURODEGENERATION (2016)

Article Clinical Neurology

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

Michael W. Weiner et al.

ALZHEIMERS & DEMENTIA (2015)

Article Clinical Neurology

Potential role of antimicrobial peptides in the early onset of Alzheimer's disease

Mick M. Welling et al.

ALZHEIMERS & DEMENTIA (2015)

Article Neurosciences

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

Severin Filser et al.

BIOLOGICAL PSYCHIATRY (2015)

Article Chemistry, Medicinal

Prospects of -Secretase Inhibitors for the Treatment of Alzheimer's Disease

Arun K. Ghosh et al.

CHEMMEDCHEM (2015)

Article Clinical Neurology

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer's Disease

Robert J. Baranello et al.

CURRENT ALZHEIMER RESEARCH (2015)

Article Medicine, Research & Experimental

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Yasuhiko Kizuka et al.

EMBO MOLECULAR MEDICINE (2015)

Review Neurosciences

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease

Sergio T. Ferreira et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Biochemistry & Molecular Biology

Computational Methods in the Discovery and Design of BACE-1 Inhibitors

P. Kacker et al.

CURRENT MEDICINAL CHEMISTRY (2015)

Review Chemistry, Multidisciplinary

BACE1 (beta-secretase) inhibitors for the treatment of Alzheimer's disease

Arun K. Ghosh et al.

CHEMICAL SOCIETY REVIEWS (2014)

Article Biochemistry & Molecular Biology

Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein

Janice A. Maloney et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

Robert Vassar et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Review Clinical Neurology

Targeting the β secretase BACE1 for Alzheimer's disease therapy

Riqiang Yan et al.

LANCET NEUROLOGY (2014)

Review Geriatrics & Gerontology

The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer's disease

Xiaofang Cheng et al.

NEUROBIOLOGY OF AGING (2014)

Editorial Material Cell Biology

Sorting the Role of SORLA in Alzheimer's Disease

Virginie Buggia-Prevot et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Clinical Neurology

BACE1 inhibitor drugs in clinical trials for Alzheimer's disease

Robert Vassar

ALZHEIMERS RESEARCH & THERAPY (2014)

Article Chemistry, Medicinal

Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies

Stefania Butini et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Review Immunology

IL-1 receptor 2 (IL-1R2) and its role in immune regulation

Vanessa A. Peters et al.

BRAIN BEHAVIOR AND IMMUNITY (2013)

Review Biochemistry & Molecular Biology

Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story

Andrew Stamford et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Allosteric inhibition of BACE1 by an exosite-binding antibody

Weiru Wang et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

Cyril Cheret et al.

EMBO JOURNAL (2013)

Article Cell Biology

Two phases of disulfide bond formation have differing requirements for oxygen

Marianne Koritzinsky et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes

Frauke van Bebber et al.

JOURNAL OF NEUROCHEMISTRY (2013)

Article Cell Biology

BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway

Xiangyou Hu et al.

CELL REPORTS (2013)

Review Neurosciences

The Upside of APP at Synapses

Hyang-Sook Hoe et al.

CNS NEUROSCIENCE & THERAPEUTICS (2012)

Article Biochemistry & Molecular Biology

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

Peer-Hendrik Kuhn et al.

EMBO JOURNAL (2012)

Review Biochemistry & Molecular Biology

Developing ß-secretase inhibitors for treatment of Alzheimer's disease

Arun K. Ghosh et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Multidisciplinary Sciences

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline

Thorlakur Jonsson et al.

NATURE (2012)

Article Multidisciplinary Sciences

The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease

Luxiang Cao et al.

SCIENTIFIC REPORTS (2012)

Article Medicine, Research & Experimental

Biochemistry of Amyloid β-Protein and Amyloid Deposits in Alzheimer Disease

Colin L. Masters et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Pharmacology & Pharmacy

Principles of early drug discovery

J. P. Hughes et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1

Lujia Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination

Xiaoyang Luo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

Ming Jin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

Jasvinder K. Atwal et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Neurosciences

The Role of Seizure-Related SEZ6 as a Susceptibility Gene in Febrile Seizures

John C. Mulley et al.

NEUROLOGY RESEARCH INTERNATIONAL (2011)

Review Neurosciences

Amyloid-beta as a Modulator of Synaptic Plasticity

Mordhwaj S. Parihar et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Biochemistry & Molecular Biology

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

Eugene L. Kang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease A NOVEL TOOL FOR THERAPY AND DIAGNOSIS

Oliver Wirths et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Neurosciences

BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

Xiangyou Hu et al.

JOURNAL OF NEUROSCIENCE (2010)

Review Clinical Neurology

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Clifford R. Jack et al.

LANCET NEUROLOGY (2010)

Article Multidisciplinary Sciences

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

Hyunbum Jang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Crystal structure of human pepsin and its complex with pepstatin

Masao Fujinaga et al.

PROTEIN SCIENCE (2010)

Article Biochemistry & Molecular Biology

Predicting memapsin 2 (β-secretase) hydrolytic activity

Xiaoman Li et al.

PROTEIN SCIENCE (2010)

Article Multidisciplinary Sciences

Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease

Kwasi G. Mawuenyega et al.

SCIENCE (2010)

Article Clinical Neurology

The basics of preclinical drug development for neurodegenerative disease indications

Karen L. Steinmetz et al.

BMC NEUROLOGY (2009)

Article Biochemistry & Molecular Biology

Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts

Kulandaivelu S. Vetrivel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

Michela Guglielmotto et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Review Biochemical Research Methods

Multifunctional aspartic peptidase prosegments

Yasumi Horimoto et al.

NEW BIOTECHNOLOGY (2009)

Article Multidisciplinary Sciences

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

Matthew L. Hemming et al.

PLOS ONE (2009)

Review Chemistry, Medicinal

Design of potent aspartic protease inhibitors to treat various diseases

Jeffrey-Tri Nguyen et al.

ARCHIV DER PHARMAZIE (2008)

Review Neurosciences

Requirements for a lead compound to become a clinical candidate

Franz F. Hefti

BMC NEUROSCIENCE (2008)

Article Biochemistry & Molecular Biology

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

Xiangyou Hu et al.

FASEB JOURNAL (2008)

Review Immunology

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

Solomon S. Shaftel et al.

JOURNAL OF NEUROINFLAMMATION (2008)

Article Biochemistry & Molecular Biology

Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production

Hideaki Shimizu et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease-like pathology

Stephan Schilling et al.

NATURE MEDICINE (2008)

Article Geriatrics & Gerontology

BACE1 gene deletion:: Impact on behavioral function in a model of Alzheimer's disease

Dione Kobayashi et al.

NEUROBIOLOGY OF AGING (2008)

Review Clinical Neurology

β-secretase as a therapeutic target for Alzheimer's disease

Arun K. Ghosh et al.

NEUROTHERAPEUTICS (2008)

Article Multidisciplinary Sciences

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

A. V. Savonenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1

Claudio Costantini et al.

BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization

Wan-Pin Chang et al.

FASEB JOURNAL (2007)

Article Cell Biology

BACE1 regulates voltage-gated sodium channels and neuronal activity

Doo Yeon Kim et al.

NATURE CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Regulated intramembrane proteolysis of the interleukin-1 receptor II by α-, β-, and γ-secretase

Peer-Hendrik Kuhn et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation

Xian Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Cell Biology

Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide

Christian Haass et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

A beta Oligomers - a decade of discovery

Dominic M. Walsh et al.

JOURNAL OF NEUROCHEMISTRY (2007)

Article Multidisciplinary Sciences

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

Xiulian Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Neurosciences

Bace1 modulates myelination in the central and peripheral nervous system

Xiangyou Hu et al.

NATURE NEUROSCIENCE (2006)

Article Multidisciplinary Sciences

Control of peripheral nerve myelination by the β-secretase BACE1

Michael Willem et al.

SCIENCE (2006)

Review Neurosciences

Physiological roles for amyloid β peptides

Hugh A. Pearson et al.

JOURNAL OF PHYSIOLOGY-LONDON (2006)

Article Biochemistry & Molecular Biology

Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

JA Johnston et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2005)

Article Biochemistry & Molecular Biology

BACE is degraded via the lysosomal pathway

YH Koh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

D Dominguez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

An alternative interpretation of the amyloid Aβ hypothesis with regard to the pathogenesis of Alzheimer's disease

VT Marchesi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease

C Lindberg et al.

NEUROCHEMISTRY INTERNATIONAL (2005)

Article Multidisciplinary Sciences

Inhibition of amyloid precursor protein processing by β-secretase through site-directed antibodies

M Arbel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

The low density lipoprotein receptor-related protein (LRP) is a novel β-secretase (BACE1) substrate

CAF von Arnim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

GGA proteins mediate the recycling pathway of memapsin 2 (BACE)

XY He et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Chemistry, Medicinal

Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease

AK Ghosh et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Axonal neuregulin-1 regulates myelin sheath thickness

GV Michailov et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

In vivo inhibition of Aβ production by memapsin 2 (β-secretase) inhibitors

WP Chang et al.

JOURNAL OF NEUROCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1

SF Lichtenthaler et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Neurosciences

APP processing and synaptic function

F Kamenetz et al.

NEURON (2003)

Article Clinical Neurology

β-secretase protein and activity are increased in the neocortex in Alzheimer disease

H Fukumoto et al.

ARCHIVES OF NEUROLOGY (2002)

Article Clinical Neurology

Increased expression of the amyloid precursor β-secretase in Alzheimer's disease

RMD Holsinger et al.

ANNALS OF NEUROLOGY (2002)

Article Multidisciplinary Sciences

Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

S Kitazume et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Letter Chemistry, Medicinal

Structure-based design:: Potent inhibitors of human brain memapsin 2 (β-secretase)

AK Ghosh et al.

JOURNAL OF MEDICINAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Subsite specificity of memapsin 2 (β-secretase):: Implications for inhibitor design

RT Turner et al.

BIOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase

BD Bennett et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Maturation and pro-peptide cleavage of β-secretase

A Capell et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)