期刊
MOLECULES
卷 22, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/molecules22071071
关键词
Leishmania mexicana mexicana; essential oils; Ocimum gratissimum; Cinnamomum cassia; Zingiber zerumbet; Elsholtzia ciliata; Amomum aromaticum; eugenol
资金
- Vietnamese Ministry of Education and Training
- Belgian National Fund for Scientific Research (FNRS) [PDR T.0190.13]
Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. In our researches for new safe and effective treatments, thirty-seven essential oils (EOs) extracted from Vietnamese plants were screened in vitro for the first time on Leishmania mexicana mexicana (Lmm) promastigotes at the maximum concentration of 50 nL/mL. Active EOs were also analyzed for cytotoxicity on mammalian cell lines (WI38, J774) and their selectivity indices (SI) were calculated. Their composition was determined by GC-MS and GC-FID. Our results indicated that EOs extracted from Cinnamomum cassia, Zingiber zerumbet, Elsholtzia ciliata and Amomum aromaticum, possessed a moderate anti-leishmanial activity, with IC50 values of 2.92 +/- 0.08, 3.34 +/- 0.34, 8.49 +/- 0.32 and 9.25 +/- 0.64 nL/mL respectively. However, they also showed cytotoxicity with SI < 10. The most promising EO was extracted from Ocimum gratissimum, displaying an IC50 of 4.85 +/- 1.65 nL/mL and SI > 10. It contained 86.5% eugenol, which was demonstrated to be effective on Lmm with IC50 of 2.57 +/- 0.57 nL/mL and not toxic on mammalian cells, explaining the observed activity.
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