期刊
MOLECULES
卷 22, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules22020275
关键词
alpha-mangostin; anti-bacterial; anti-fungal; packaging; textiles; biomedical device; semi-synthetic modification
资金
- Italian Ministry for Innovation [PON02_00186_3417512S.I.Mi.S.A.]
The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified -mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of -mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified -mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.
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