期刊
MOLECULES
卷 22, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/molecules22010106
关键词
Radix Cyathulae polysaccharide; phosphorylation modification; adjuvant; dendritic cell
资金
- National Natural Science Foundation of China [31402238]
- Advanced and Applied Basic research Program [cstc2015jcyjA80023]
- Fundamental Research Funds for the Central Universities [SWU113091]
- Foundation of Chengdu University [2015XJZ07]
The aim of this study was to investigate whether phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) used as adjuvant with foot-and-mouth disease vaccine (FMDV) can stimulate specific humoral and cellular immune responses in ICR mice. The results demonstrated that pRCPS significantly up-regulated FMDV-specific IgG, IgG1, IgG2b and IgG2a antibody levels and splenocyte proliferation. pRCPS also promoted the killing activities of cytotoxic T lymphocytes (CTL) and natural killer cells (NK). In addition, pRCPS enhanced the expression levels of IL-2, IL-4, and IFN- in CD4(+) T cells and the level of IFN- in CD8(+) T cells. Importantly, pRCPS enhanced the expression of MHCII, CD40(+), CD86(+), and CD80(+) in dendritic cells (DCs). This study indicated that phosphorylation modification could increase immune-enhancing activities of RCPS, and pRCPS could promote humoral and cellular immune responses through facilitating DC maturation.
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