期刊
MOLECULES
卷 22, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/molecules22050757
关键词
thiazoles; multi-component reaction; Hantzsch condensation; heterogeneous catalysis; antioxidant; antibacterial
资金
- Ministry of Higher Education and Scientific Research (Algeria)
- National Center of the scientific research
- Ministry of Education, Research, and Technology (France)
An efficient and green method has been developed for the synthesis of new substituted Hantzsch thiazole derivatives in 79%-90% yield, via the one-pot multi-component procedure, by the reaction of 3-(bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, thiourea and substituted benzaldehydes in the presence of silica supported tungstosilisic acid, as a reusable catalyst, under conventional heating or under ultrasonic irradiation. The catalyst is recoverable by a simple filtration and can be reused in the subsequent reactions. Most of the thiazoles exhibited significant antibacterial activity compared toamoxicillin and ciprofloxacin as positive controls. In addition, the new compounds showed moderate to good antioxidant (DPPH) radical scavenging activity.
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