期刊
CHEMICAL SOCIETY REVIEWS
卷 48, 期 1, 页码 22-37出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cs00494c
关键词
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资金
- NNSF of China [61525402, 61775095]
- Jiangsu Provincial Key Research and Development Plan [BE2017741]
- Jiangsu Provincial Natural Science Foundation [BK20180136, BK20160051]
- Fundamental Research Funds for the Central Universities [021414380350]
- Nanjing Foundation for Development of Science and Technology [2017sc512031, 201605042]
The optical technology presents non-invasive, non-destructive, and non-ionizing features and has the ability to display various chemical components in tissues to provide useful information for various biomedical applications. Regarding selection of light wavelengths, second near-infrared (NIR-II, 900-1700 nm) light is a much better choice compared to both visible (380-780 nm) and traditional near-infrared (780-900 nm) light, because of its advantages including deeper penetration into biological tissues, less tissue scattering or absorption, and decreased interference by fluorescent proteins. Thus, using optical nano-agents that absorb or emit light in the NIR-II window can achieve deeper tissue optical imaging with higher signal-to-background ratios and better spatial resolution for diagnosis. What's more, some of these nano-agents can be further applied for imaging guided surgical removal, real-time monitoring of drug delivery, labeling lymphatic metastasis, biosensing, and imaging guided phototherapy. In this review, we attempt to summarize the recent advances of various NIR-II nano-agents (including single-walled carbon nanotubes, quantum dots, rare-earth doped nanoparticles, other inorganic nanomaterials, small organic molecule-based nanoparticles, and semiconducting polymer nanoparticles) in both bioimaging and therapeutic applications, and discuss the challenges and perspectives of these nano-agents for clinical practice in the near future.
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