期刊
MOLECULAR THERAPY
卷 25, 期 2, 页码 314-320出版社
CELL PRESS
DOI: 10.1016/j.ymthe.2016.11.011
关键词
-
资金
- NIH [K08CA166039]
- Gabrielle's Angel Foundation
- V Foundation
Autologous T cells modified to recognize novel antigen targets are a novel form of therapy for cancer. We review the various potential forms of observed and hypothetical toxicities associated with genetically modified T cells. Despite the focus on toxicities in this review, re-directed T cells represent a powerful and highly effective form of anti-cancer therapy; we remain optimistic that the common toxicities will become routinely manageable and that some theoretical toxicity will be exceedingly rare, if ever observed.
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