期刊
MOLECULAR SYSTEMS BIOLOGY
卷 13, 期 9, 页码 -出版社
WILEY
DOI: 10.15252/msb.20156297
关键词
biomarkers; diagnostic; mass spectrometry; plasma proteomics; systems medicine
资金
- Max Planck Society for the Advancement of Science
- Novo Nordisk Foundation [NNF15CC0001]
- Novo Nordisk Fonden [NNF15SA0018240] Funding Source: researchfish
- Novo Nordisk Foundation Center for Protein Research [PI Matthias Mann] Funding Source: researchfish
Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (MS)-based proteomics has become a powerful technology in biological research and it is now poised to allow the characterization of the plasma proteome in great depth. Previous triangular strategies aimed at discovering single biomarker candidates in small cohorts, followed by classical immunoassays in much larger validation cohorts. We propose a rectangular plasma proteome profiling strategy, in which the proteome patterns of large cohorts are correlated with their phenotypes in health and disease. Translating such concepts into clinical practice will require restructuring several aspects of diagnostic decision-making, and we discuss some first steps in this direction.
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