期刊
NEW JOURNAL OF CHEMISTRY
卷 43, 期 1, 页码 93-102出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nj04294b
关键词
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资金
- Council of Scientific & Industrial Research New Delhi (India)
- Science and Engineering Research Board, New Delhi [EMR/2017/000155, SB/FT/CS-188/2011]
- Council of Scientific & Industrial Research New Delhi (India) [(02) 0202/14/EMR-II]
- TEQIP-III (NIT Jalandhar)
An efficient protocol has been developed for one-pot synthesis of biologically interesting -carboline substituted 1,3,4-oxadiazoles via an I-2-assisted oxidative C-O bond formation strategy. This metal-free sequential approach is found to be compatible with diversely substituted 1-formyl -carbolines and aromatic as well as aliphatic hydrazides, providing access to a variety of multifunctional -carboline linked 1,3,4-oxadiazole derivatives in good to excellent yields. The methodology was found to be applicable to gram scale synthesis of -carboline substituted 1,3,4-oxadiazole derivatives. Additionally, -carboline C1 linked 2-amino-1,3,4-oxadiazoles and bis-1,3,4-oxadiazoles were also synthesized using the same strategy.
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