期刊
MOLECULAR PSYCHIATRY
卷 23, 期 7, 页码 1652-1658出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2017.215
关键词
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资金
- Tourette Association of America
- Swedish Brain Foundation
- Alicia Koplowitz Foundation
- Swedish Research Council for Health, Working Life and Welfare (FORTE) [201500569]
- NIMH [R01MH105500, R01MH110427]
- Swedish Research Council [K2013-61P-22168]
- Swedish Research Council through the SIMSAM (Swedish Initiative for Research on Microdata in the Social And Medical Sciences) [340-2013-5867]
- Swedish Research Council for Health, Working Life and Welfare
- Swedish Research Council
The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013. The risk of 40 ADs was evaluated in individuals with OCD, individuals with TD/CTD and their first-(siblings, mothers, fathers), second-(half siblings) and third-degree (cousins) relatives, compared with population controls. Individuals with OCD and TD/CTD had increased comorbidity with any AD (43% and 36%, respectively) and many individual ADs. The risk of any AD and several individual ADs was consistently higher among first-degree relatives than among second-and third-degree relatives of OCD and TD/CTD probands. The risk of ADs was very similar in mothers, fathers and siblings of OCD probands, whereas it tended to be higher in mothers and fathers of TD/CTD probands (compared with siblings). The results suggest a familial link between ADs in general (that is, not limited to Streptococcus-related conditions) and both OCD and TD/CTD. Additional mother-specific factors, such as the placental transmission of antibodies, cannot be fully ruled out, particularly in TD/CTD.
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