期刊
MOLECULAR PSYCHIATRY
卷 23, 期 3, 页码 674-682出版社
SPRINGERNATURE
DOI: 10.1038/mp.2017.23
关键词
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资金
- National Institute for Health Research Doctoral Research Fellowship [DRF-2011-04-076]
- Medical Research Council (United Kingdom) intramural programme [MRC-A060-5PR50]
- Karolinska Institutet
- Medical Research Council Clinician Scientist Fellowship [G0802821]
- Wellcome Trust Senior Investigator Award [104571/Z/14/Z]
- United Kingdom Medical Research Council [MC-A060-5PR50]
- Medical Research Council [MC_EX_G0802821, MC_UU_00005/15, MC_U105579212, MC_UP_0901/1, MC_UU_00005/14] Funding Source: researchfish
- MRC [MC_UP_0901/1, MC_UU_00005/14, MC_U105579212, MC_UU_00005/15, MC_EX_G0802821] Funding Source: UKRI
After psychological trauma, recurrent intrusive visual memories may be distressing and disruptive. Preventive interventions post trauma are lacking. Here we test a behavioural intervention after real-life trauma derived from cognitive neuroscience. We hypothesized that intrusive memories would be significantly reduced in number by an intervention involving a computer game with high visuospatial demands (Tetris), via disrupting consolidation of sensory elements of trauma memory. The Tetris-based intervention (trauma memory reminder cue plus c. 20 min game play) vs attention-placebo control (written activity log for same duration) were both delivered in an emergency department within 6 h of a motor vehicle accident. The randomized controlled trial compared the impact on the number of intrusive trauma memories in the subsequent week (primary outcome). Results vindicated the efficacy of the Tetris-based intervention compared with the control condition: there were fewer intrusive memories overall, and time-series analyses showed that intrusion incidence declined more quickly. There were convergent findings on a measure of clinical post-trauma intrusion symptoms at 1 week, but not on other symptom clusters or at 1 month. Results of this proof-of-concept study suggest that a larger trial, powered to detect differences at 1 month, is warranted. Participants found the intervention easy, helpful and minimally distressing. By translating emerging neuroscientific insights and experimental research into the real world, we offer a promising new low-intensity psychiatric intervention that could prevent debilitating intrusive memories following trauma.
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