期刊
MOLECULAR PSYCHIATRY
卷 23, 期 4, 页码 932-942出版社
SPRINGERNATURE
DOI: 10.1038/mp.2017.73
关键词
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资金
- NIH Big Data to Knowledge (BD2K) award [U54 EB020403]
- Canadian Institutes of Health Research [103703, 106469, 64410, 142255]
- Nova Scotia Health Research Foundation
- Dalhousie Clinical Research Scholarship
- Research Council of Norway [223273, 213837, 249711]
- South East Norway Health Authority [2017-112]
- Kristian Gerhard Jebsen Stiftelsen [SKGJ-MED-008]
- European Community's Seventh Framework Programme (FP7) [602450]
- National Centre for Mental Health (NCMH)
- Bipolar Disorder Research Network (BDRN)
- NARSAD Young Investigator Award [17319]
- French National Agency for Research (ANR MNP)
- Fondation pour la Recherche Medicale (Bio-informarcis grant)
- Swedish Medical Research Council
- Swedish foundation for Strategic Research
- Swedish Brain foundation
- Swedish Federal Government under the LUA/ALF agreement
- South East Norway Health Authority
- NIH [MH085667, R01MH075007, R01MH095454, P30NS062691, K23MH074644-01, K08MH086786, K23MH098130, K23MH085096, R01MH107703, R01MH101111]
- NIMH [R01 MH090553, K01MH096077]
- Brain Behavior Research Foundation
- Stanley Medical Research Institute
- CIBERSAM
- Spanish Ministry of Economy and Competitiveness [PI 12/00910]
- Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya [2014 SGR 398, 2014-SGR-1573]
- MRC Fellowship [MR/J008915/1]
- Health Research Board [HRA_POR/2011/100]
- Australian National Medical and Health Research Council [1037196, 1066177]
- Lansdowne Foundation
- National Institute of Mental Health [R01MH104284]
- NARSAD Young Investigator Award
- Psychiatric Research Trust grant
- German Research Foundation (DFG) [FOR2107, DA1151/5-1]
- Brain and Behavior Research Foundation
- William K. Warren Foundation
- NIMH
- Pittsburgh Foundation
- FAPESP-Brazil [2009/14891-9, 2010/18672-7, 2012/23796-2, 2013/03905-4]
- CNPq-Brazil [478466/2009, 480370/2009]
- Wellcome Trust (UK)
- Brain AMP
- Behavior Research Foundation (NARSAD Independent Investigator Award)
- German Federal Ministry of Education and Research (BMBF)
- Organization for Health Research and Development (ZonMw), program Mental Health, education of investigators in mental health (OOG) [100-002-034]
- Deutsche Forschungsgemeinschaft (DFG) [241, GR 1950/5-1]
- Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya
- Instituto de Salud Carlos III (European Regional Development Fund/European Social Fund) [CPII16/00018]
- Instituto de Salud Carlos III (European Regional Development Fund/European Social Fund) Investing in your future) [CD16/00264]
- [5R01MH076971]
- [PI14/01148]
- [PI15/00277]
- MRC [MR/J008915/1] Funding Source: UKRI
- Medical Research Council [MR/J008915/1, 1578661] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0616-10091] Funding Source: researchfish
- Health Research Board (HRB) [HRA-POR-2011-100] Funding Source: Health Research Board (HRB)
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen's d =-0.293; P = 1.71 x 10(-21)), left fusiform gyrus (d =-0.288; P = 8.25 x 10(-21)) and left rostral middle frontal cortex (d =-0.276; P = 2.99 x 10(-19)). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD.
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