期刊
MOLECULAR PHARMACOLOGY
卷 92, 期 3, 页码 232-239出版社
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/mol.116.108142
关键词
-
资金
- National Nature Scientific Foundation [81473233, 81600878]
- International Collaboration Science Research Foundation of Guangdong Province [2013B051000046]
- Medical Science and Technology Research Fund of Guangdong Province [B2013145]
- Natural Science Foundation of Guangdong Province [2016A030310217]
- Medical Scientific Research Foundation of Guangdong Province [A2016096]
Screening for circulating tumor cells (CTCs) has been identified as one approach to ultrasensitive liquid biopsy in real-time monitoring of cancer patients. The detection of CTCs in peripheral blood from cancer patients is promising as a diagnostic tool; however, the application of CTCs in therapeutic treatment still faces serious challenges with respect to specificity and sensitivity. Here, we review the significant roles of CTCs in metastasis and the strengths and weaknesses of the currently available methods for CTC detection and characterization. Moreover, we discuss the clinical application of CTCs as markers for patient prognosis, and we specifically focus on the application of CTCs as indicators in cancer pharmacotherapy. Characterization of the detected CTCs will provide new biologic perspectives and clinical applications for the treatment of cancer patients with metastasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据