期刊
BIOENGINEERING-BASEL
卷 6, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/bioengineering6010009
关键词
organoids; brain organoids; neurodevelopment; disorders
资金
- Israel Science Foundation [347/15]
- Legacy Heritage Biomedical Program of the Israel Science Foundation [2041/16]
- ISF-NSFC joint research program [2449/16]
- Canadian Institutes of Health Research (CIHR) [2397/18]
- IMOH [3-0000-12276]
- German-Israeli Foundation (GIF) [I-1476-203.13/2018]
- United States - Israel Binational Science Foundation (BSF) [2017006]
- Nella and Leon Benoziyo Center for Neurological Diseases
- Jeanne and Joseph Nissim Foundation for Life Sciences Research
- Wohl Biology Endowment Fund
- Lulu P. and David J. Levidow Fund for Alzheimer's Diseases and Neuroscience Research
- Helen and Martin Kimmel Stem Cell Research Institute
- Kekst Family Institute for Medical Genetics
- David and Fela Shapell Family Center for Genetic Disorders Research
- Human Frontier Science Program [LT000629/2018-L]
- International Development Research Centre (IDRC)
- Israel Science Foundation (ISF)
- ERA-NET Neuron
Brain organoids have recently emerged as a three-dimensional tissue culture platform to study the principles of neurodevelopment and morphogenesis. Importantly, brain organoids can be derived from human stem cells, and thus offer a model system for early human brain development and human specific disorders. However, there are still major differences between the in vitro systems and in vivo development. This is in part due to the challenge of engineering a suitable culture platform that will support proper development. In this review, we discuss the similarities and differences of human brain organoid systems in comparison to embryonic development. We then describe how organoids are used to model neurodevelopmental diseases. Finally, we describe challenges in organoid systems and how to approach these challenges using complementary bioengineering techniques.
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