期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 7, 页码 883-896出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc07828a
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资金
- GlaxoSmithKline (GSK)
- Singapore Economic Development Board (EDB) through a Green and Sustainable Manufacturing Grant [279-000-348-592]
- National University of Singapore through Synthetic Biology for Clinical and Technological Innovation (SynCTI) Program
Alkenes are excellent starting materials for organic synthesis due to the versatile reactivity of C=C bonds and the easy availability of many unfunctionalised alkenes. Direct regio- and/or enantioselective conversion of alkenes into functionalised (chiral) compounds has enormous potential for industrial applications, and thus has attracted the attention of researchers for extensive development using chemo-catalysis over the past few years. On the other hand, many enzymes have also been employed for conversion of alkenes in a highly selective and much greener manner to offer valuable products. Herein, we review recent advances in seven well-known types of biocatalytic conversion of alkenes. Remarkably, recent mechanism-guided directed evolution and enzyme cascades have enabled the development of seven novel types of single-step and one-pot multi-step functionalisation of alkenes, some of which are even unattainable via chemo-catalysis. These new reactions are particularly highlighted in this feature article. Overall, we present an ever-expanding enzyme toolbox for various alkene functionalisations inspiring further research in this fast-developing theme.
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