期刊
MOLECULAR PHARMACOLOGY
卷 92, 期 3, 页码 240-245出版社
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/mol.116.107730
关键词
-
资金
- National Natural Science Foundation of China [31271444, 81201726, 8161101021]
- Guangdong Natural Science Funds for Distinguished Young Scholar [2014A030306001]
- Guangdong Special Support Program for Young Talent [2015TQ01R350]
- Science and Technology Program of Guangdong [2016A050502027]
- Foundation for Research Cultivation and Innovation of Jinan University [21616119]
Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and beta-catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据