期刊
MOLECULAR PHARMACEUTICS
卷 14, 期 8, 页码 2624-2628出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.7b00325
关键词
nanogels; drug delivery; stimuli-responsive polymers; biomolecular coatings
资金
- University of Alberta (the Department of Chemistry)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Foundation for Innovation (CFI)
- Alberta Advanced Education & Technology Small Equipment Grants Program (AET/SEGP)
- Grand Challenges Canada
- IC-IMPACTS
- Alberta Innovates Technology Futures (AITF) Postdoctoral Fellowship
- National Science Foundation of China [21604091]
- MacEwan Research
- University of Alberta (Faculty of Science)
Nanogels with a biomolecular coating (biocoating) were shown to be, capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon exposure to glucose and changes in solution pH. We also show the nanogel's thermoresponsivity can be used to accelerate Doxorubicin release. Moreover, we showed that transferrin immobilized on the nanogel surface could accelerate nanogel uptake by cancer cells. In these experiments, we showed that Doxorubicin was able to be released to the nucleus of human liver cancer cell line (HepG2) within 3 h. Doxorubicin-loaded nanogels exhibit a strong growth inhibition ability toward HepG2. This investigation showcases how nanogel design and chemistry can be tuned to achieve useful biomedical applications.
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