期刊
MOLECULAR ONCOLOGY
卷 11, 期 7, 页码 792-804出版社
WILEY
DOI: 10.1002/1878-0261.12096
关键词
epithelial-mesenchymal transition; metastasis; plasticity; stemness
类别
资金
- Ministry of Science and Technology [104-2321-B-010-005, 104-0210-01-09-02, 103-2633-H-010-001]
- Taipei Veterans General Hospital [V106C-090, VTA106-V1-3-3]
- Ministry of Education, Aim for the Top University Plan
- Ministry of Health and Welfare, Center of Excellence for Cancer Research [MOHW106-TDU-B-211-144-003]
Epithelial-mesenchymal transition (EMT) is an important process in embryonic development, fibrosis, and cancer metastasis. During cancer progression, the activation of EMT permits cancer cells to acquire migratory, invasive, and stem-like properties. A growing body of evidence supports the critical link between EMT and cancer stemness. However, contradictory results have indicated that the inhibition of EMT also promotes cancer stemness, and that mesenchymal-epithelial transition, the reverse process of EMT, is associated with the tumor-initiating ability required for metastatic colonization. The concept of 'intermediate-state EMT' provides a possible explanation for this conflicting evidence. In addition, recent studies have indicated that the appearance of 'hybrid' epithelial-mesenchymal cells is favorable for the establishment of metastasis. In summary, dynamic changes or plasticity between the epithelial and the mesenchymal states rather than a fixed phenotype is more likely to occur in tumors in the clinical setting. Further studies aimed at validating and consolidating the concept of intermediate-state EMT and hybrid tumors are needed for the establishment of a comprehensive profile of cancer metastasis.
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