期刊
MOLECULAR ONCOLOGY
卷 11, 期 12, 页码 1673-1686出版社
WILEY
DOI: 10.1002/1878-0261.12144
关键词
cell-cell communication; circulating miRNAs; exosomes; extracellular vesicles; microRNAs; tumor microenvironment
类别
资金
- National Institutes of Health (NIH/NCATS) through the NIH Common Fund [UH3TR00943-01]
- Office of Strategic Coordination (OSC)
- NIH/NCI [1 R01 CA182905-01]
- UPR/MDACC Partnership for Excellence in Cancer Research
- DOD [CA160445P1]
- Ladies Leukemia League Grant
- CLL Moonshot Flagship Project
- SINF
- Estate of C. G. Johnson
- Lauri Strauss Leukemia Foundation
Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell-to-cell communication within the tumor microenvironment. EVs' components, such as proteins, noncoding RNAs [microRNAs (miRNAs), and long noncoding RNAs (lncRNAs)], messenger RNAs (mRNAs), DNA, and lipids, can mediate paracrine signaling in the tumor microenvironment. Recently, miRNAs encapsulated in secreted EVs have been identified in the extracellular space. Mature miRNAs that participate in intercellular communication are released from most cells, often within EVs, and disseminate through the extracellular fluid to reach remote target cells, including tumor cells, whose phenotypes they can influence by regulating mRNA and protein expression either as tumor suppressors or as oncogenes, depending on their targets. In this review, we discuss the roles of miRNAs in intercellular communication, the biological function of extracellular miRNAs, and their potential applications for diagnosis and therapeutics. We will give examples of miRNAs that behave as hormones.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据