期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 61, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.201700261
关键词
Brown adipose tissue; Cyanidin-3-glucoside; Energy metabolism; Mitochondrial function; Obesity
资金
- Science and Technology Project in Beijing [D161100005416002]
- National Twelfth Five-Year Plan for Science and Technology [2012BAD31B07, 2012BAD31B05]
- National Natural Science Foundation of China [81500659]
Scope: Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue (BAT) formation and function increases energy expenditure and may protect against obesity. Cyanidin-3-glucoside (C3G) is an anthocyanin compound that occurs naturally in many fruits and vegetables. In this study, we investigated the effect and mechanism of C3G on the prevention of obesity. Methods and results: Db/db mice received C3G dissolved in drinking water for 16 wk; drinking water served as the vehicle treatment. The total body weight, energy intake, metabolic rate, and physical activity were measured. The lipid droplets, gene expression and protein expression were evaluated by histochemical staining, real-time PCR, and western blots. We found that C3G increased energy expenditure, limited weight gain, maintained glucose homeostasis, reversed hepatic steatosis, improved cold tolerance, and enhanced BAT activity in obese db/db mice. C3G also induces brown-like adipocytes (beige) formation in subcutaneous white adipose tissue (sWAT) of db/db mice model. We also found that C3G potently regulates the transcription of uncoupling protein 1 (UCP1) both in BAT and sWAT through increasing mitochondrial number and function. Conclusion: Our results suggest that C3G plays a role in regulating systemic energy balance, which may have potential therapeutic implications for the prevention and control of obesity.
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