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ALZHEIMERS & DEMENTIA (2014)
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Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
Margarita Giraldo et al.
NEUROBIOLOGY OF AGING (2013)
A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
Rita Guerreiro et al.
NEUROBIOLOGY OF AGING (2013)
TREM2 is associated with the risk of Alzheimer's disease in Spanish population
Bruno A. Benitez et al.
NEUROBIOLOGY OF AGING (2013)
Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer's Disease
Kurt M. Lucin et al.
NEURON (2013)
Regulation of TREM2 expression by an NF-κB-sensitive miRNA-34a
Yuhai Zhao et al.
NEUROREPORT (2013)
TREM2 and Neurodegenerative Disease
Christiane Reitz et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Variant TREM2 as Risk Factor for Alzheimer's Disease
Harald Neumann et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Thorlakur Jonsson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
TREM2 Variants in Alzheimer's Disease
Rita Guerreiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke
Matthias W. Sieber et al.
PLOS ONE (2013)
Analysis of the Host Transcriptome from Demyelinating Spinal Cord of Murine Coronavirus-Infected Mice
Ruth Elliott et al.
PLOS ONE (2013)
Differential Modulation of TREM2 Protein during Postnatal Brain Development in Mice
Mariela Chertoff et al.
PLOS ONE (2013)
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection
Ligia Antunes Goncalves et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
A Physical Interaction Between the Adaptor Proteins DOK3 and DAP12 Is Required to Inhibit Lipopolysaccharide Signaling in Macrophages
Qisheng Peng et al.
SCIENCE SIGNALING (2013)
Biology of the TAM Receptors
Greg Lemke
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia-like Syndrome Without Bone Involvement
Rita Joao Guerreiro et al.
JAMA NEUROLOGY (2013)
TREM-2 Promotes Host Resistance Against Pseudomonas aeruginosa Infection by Suppressing Corneal Inflammation via a PI3K/Akt Signaling Pathway
Mingxia Sun et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)
Genome-wide Association and Population Genetic Analysis of C-Reactive Protein in African American and Hispanic American Women
Alex P. Reiner et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation
M. S. F. Zawawi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Gene Expression Profile of THP-1 Monocytes Following Knockdown of DAP12, A Causative Gene for Nasu-Hakola Disease
Jun-ichi Satoh et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2012)
TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
Hiroaki Ito et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2012)
Specific lipid recognition is a general feature of CD300 and TREM molecules
John P. Cannon et al.
IMMUNOGENETICS (2012)
TLT-1s, Alternative Transcripts of Triggering Receptor Expressed on Myeloid Cell-like Transcript-1 (TLT-1), Inhibits the Triggering Receptor Expressed on Myeloid Cell-2 (TREM-2)-mediated Signaling Pathway during Osteoclastogenesis
Soo-Hyun Yoon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
E Proteins Regulate Osteoclast Maturation and Survival
Courtney L. Long et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
TREM2 and β-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis
Karel Otero et al.
JOURNAL OF IMMUNOLOGY (2012)
Acute injury in the peripheral nervous system triggers an alternative macrophage response
Elke Ydens et al.
JOURNAL OF NEUROINFLAMMATION (2012)
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids
Rosa Rademakers et al.
NATURE GENETICS (2012)
Immunomodulation by Transplanted Human Embryonic Stem Cell-Derived Oligodendroglial Progenitors in Experimental Autoimmune Encephalomyelitis
Heechul Kim et al.
STEM CELLS (2012)
Inflammatory response in rat lungs with recurrent exposure to welding fumes: a transcriptomic approach
Jung-Hwa Oh et al.
TOXICOLOGY AND INDUSTRIAL HEALTH (2012)
The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints
Tania N. Crotti et al.
ARTHRITIS RESEARCH & THERAPY (2012)
In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice
Saki Fujimoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family
Y. Numasawa et al.
EUROPEAN JOURNAL OF NEUROLOGY (2011)
Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy
Shannon K. O'Neill et al.
IMMUNITY (2011)
A Japanese Case with Nasu-Hakola Disease of DAP12 Gene Mutation Exhibiting Precuneus Hypoperfusion
Kiyotaka Nakamagoe et al.
INTERNAL MEDICINE (2011)
Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration
Katie Lunnon et al.
JOURNAL OF IMMUNOLOGY (2011)
Immunohistochemical characterization of microglia in Nasu-Hakola disease brains
Jun-ichi Satoh et al.
NEUROPATHOLOGY (2011)
Adipose tissue transcriptome changes during obesity development in female dogs
Ryan W. Grant et al.
PHYSIOLOGICAL GENOMICS (2011)
Vasoactive intestinal peptide re-balances TREM-1/TREM-2 ratio in acute lung injury
Guo-Ying Sun et al.
REGULATORY PEPTIDES (2011)
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
Benoit Melchior et al.
ASN NEURO (2010)
Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells
Liina Tserel et al.
BMC GENOMICS (2010)
Lectins as pattern recognition molecules: The effects of epitope density in innate immunity
Tarun K. Dam et al.
GLYCOBIOLOGY (2010)
The Linker for Activation of B Cells (LAB)/Non-T Cell Activation Linker (NTAL) Regulates Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Signaling and Macrophage Inflammatory Responses Independently of the Linker for Activation of T Cells
Gillian C. Whittaker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
DAP12 Is Required for Macrophage Recruitment to the Lung in Response to Cigarette Smoke and Chemotaxis toward CCL2
Laura L. Koth et al.
JOURNAL OF IMMUNOLOGY (2010)
Inflammation, microglia, and alzheimer's disease
Brent Cameron et al.
NEUROBIOLOGY OF DISEASE (2010)
T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease
Yair Fisher et al.
PLOS ONE (2010)
TREM2-and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
Qisheng Peng et al.
SCIENCE SIGNALING (2010)
Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation
Jae-Ho Chang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Gene expression profile of the bone microenvironment in human fragility fracture bone
B. Hopwood et al.
BONE (2009)
TREM and TREM-like receptors in inflammation and disease
Jill W. Ford et al.
CURRENT OPINION IN IMMUNOLOGY (2009)
The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells
Jessica A. Hamerman et al.
IMMUNOLOGICAL REVIEWS (2009)
Microarray-Based Analysis of the Lung Recovery Process After Stainless-Steel Welding Fume Exposure in Sprague-Dawley Rats
Jung-Hwa Oh et al.
INHALATION TOXICOLOGY (2009)
CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment
Niklas Mattsson et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)
TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria
Elsa-Noah N'Diaye et al.
JOURNAL OF CELL BIOLOGY (2009)
Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-γ in Human Osteoclast Precursors
Jong-Dae Ji et al.
JOURNAL OF IMMUNOLOGY (2009)
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
Christine L. Hsieh et al.
JOURNAL OF NEUROCHEMISTRY (2009)
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor
L. Stefano et al.
JOURNAL OF NEUROCHEMISTRY (2009)
No evidence for shared etiology in two demyelinative disorders, MS and PLOSL
Anna-Maija Sulonen et al.
JOURNAL OF NEUROIMMUNOLOGY (2009)
Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease
J. Cameron Thrash et al.
NEUROCHEMICAL RESEARCH (2009)
The Role of Apolipoprotein E in Alzheimer's Disease
Jungsu Kim et al.
NEURON (2009)
Efficient colonic mucosal wound repair requires Trem2 signaling
Hiroshi Seno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
Laura Piccio et al.
BRAIN (2008)
TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
Stefanie Frank et al.
GLIA (2008)
Mutations in TREM2 Lead to Pure Early-Onset Dementia Without Bone Cysts
Eliane Chouery et al.
HUMAN MUTATION (2008)
The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12
Julia F. Charles et al.
INFECTION AND IMMUNITY (2008)
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance
Tristan Bolmont et al.
JOURNAL OF NEUROSCIENCE (2008)
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease
Melanie Meyer-Luehmann et al.
NATURE (2008)
Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes
Vanesa Gomez-Pina et al.
JOURNAL OF IMMUNOLOGY (2007)
Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response
Anna Kiialainen et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2007)
Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter
Fiona Rae et al.
DEVELOPMENTAL BIOLOGY (2007)
TREM-1 ligand expression on platelets enhances neutrophil activation
Philipp Haselmayer et al.
BLOOD (2007)
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
Andrew Grupe et al.
HUMAN MOLECULAR GENETICS (2007)
TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
Kazuya Takahashi et al.
PLOS MEDICINE (2007)
Absence of TREM2 polymorphisms in patients with Alzheimer's disease and Frontotemporal Lobar Degeneration
Chiara Fenoglio et al.
NEUROSCIENCE LETTERS (2007)
Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
Harald Neumann et al.
JOURNAL OF NEUROIMMUNOLOGY (2007)
The TREM receptor family and signal integration
Julia Klesney-Tait et al.
NATURE IMMUNOLOGY (2006)
Cutting edge: TREM-2 attenuates macrophage activation
Isaiah R. Turnbull et al.
JOURNAL OF IMMUNOLOGY (2006)
Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
Jessica A. Hamerman et al.
JOURNAL OF IMMUNOLOGY (2006)
You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling
Alexander David Barrow et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2006)
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
Noriko Takegahara et al.
NATURE CELL BIOLOGY (2006)
Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis
AM Mahdy et al.
CLINICAL AND VACCINE IMMUNOLOGY (2006)
The genetic causes of basal ganglia calcification, dementia, and bone cysts:: DAP12 and TREM2
MM Bianchin et al.
NEUROLOGY (2006)
TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function
MB Humphrey et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2006)
Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: Continuous shuttling to and from the plasma membrane regulated by cell stimulation
I. Prada et al.
NEUROSCIENCE (2006)
Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis
Y Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The genetic causes of basal ganglia calcification, dementia, and bone cysts DAP12 and TREM2
HH Klünemann et al.
NEUROLOGY (2005)
Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS
A Kiialainen et al.
NEUROBIOLOGY OF DISEASE (2005)
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
K Takahashi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection
N Aoki et al.
INFECTION AND IMMUNITY (2004)
Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy - PLOSL): A dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects
MM Bianchin et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2004)
Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages
NA Begum et al.
INFECTION AND IMMUNITY (2004)
The signaling adapter protein DAP12 regulates multinucleation during osteoclast development
MB Humphrey et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2004)
A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis
S Gibot et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
G Sessa et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Impaired differentiation of osteoclasts in TREM-2-deficient individuals
M Cella et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features
J Paloneva et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Pattern recognition by TREM-2: Binding of anionic ligands
MR Daws et al.
JOURNAL OF IMMUNOLOGY (2003)
The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44
RJN Allcock et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia
CD Schmid et al.
JOURNAL OF NEUROCHEMISTRY (2002)
The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcγ receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors
K Nakamura et al.
BLOOD (2002)
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
J Paloneva et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2002)
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
DM Walsh et al.
NATURE (2002)
Innate immunity: The missing link in neuroprotection and neurodegeneration?
MD Nguyen et al.
NATURE REVIEWS NEUROSCIENCE (2002)
A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
A Bouchon et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
A Bouchon et al.
NATURE (2001)
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