4.6 Article

New Insights on Temporal Lobe Epilepsy Based on Plasticity-Related Network Changes and High-Order Statistics

期刊

MOLECULAR NEUROBIOLOGY
卷 55, 期 5, 页码 3990-3998

出版社

SPRINGER
DOI: 10.1007/s12035-017-0623-2

关键词

Epileptogenesis; Status epilepticus; Neuronal plasticity; Assortativity; Degree correlations; Networks; TLE

资金

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2014/16711-6, 2011/50151-0, 2015/50122-0]
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 308608/2014-3]
  3. DFG-IRTG [1740/2]

向作者/读者索取更多资源

Epilepsy is a disorder of the brain characterized by the predisposition to generate recurrent unprovoked seizures, which involves reshaping of neuronal circuitries based on intense neuronal activity. In this review, we first detailed the regulation of plasticity-associated genes, such as ARC, GAP-43, PSD-95, synapsin, and synaptophysin. Indeed, reshaping of neuronal connectivity after the primary, acute epileptogenesis event increases the excitability of the temporal lobe. Herein, we also discussed the heterogeneity of neuronal populations regarding the number of synaptic connections, which in the theoretical field is commonly referred as degree. Employing integrate-and-fire neuronal model, we determined that in addition to increased synaptic strength, degree correlations might play essential and unsuspected roles in the control of network activity. Indeed, assortativity, which can be described as a condition where high-degree correlations are observed, increases the excitability of neural networks. In this review, we summarized recent topics in the field, and data were discussed according to newly developed or unusual tools, as provided by mathematical graph analysis and high-order statistics. With this, we were able to present new foundations for the pathological activity observed in temporal lobe epilepsy.

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