期刊
EARLY INTERVENTION IN PSYCHIATRY
卷 13, 期 1, 页码 101-109出版社
WILEY
DOI: 10.1111/eip.12457
关键词
antipsychotic drug treatment; body mass index; first-episode psychosis; inflammatory biomarkers; metabolic biomarkers
类别
资金
- European Union through the European Regional Development Fund [2014-2020.4.01.15-0012]
- Estonian Research Foundation [IUT 20-41, IUT 20-42, IUT 20-45]
Aim Second-generation antipsychotics are commonly used to treat schizophrenia, but may cause metabolic syndrome (MetS) in a subset of patients. The mechanisms of antipsychotic-related metabolic changes remain to be established, especially in first-episode psychosis (FEP) patients. Methods In the present study, we used a chip technology to measure metabolic (C-peptide, insulin, leptin, adiponectin and resistin) and inflammatory biomarkers (ferritin, interleukin-6, interleukin-1 alpha, tumour necrosis factor-alpha and plasminogen activator inhibitor-1) in the serum samples of a population of FEP patients before and after 7 months of antipsychotic drug treatment, compared to control subjects (CS). Results The comparison of these markers in antipsychotic-naive FEP patients (N = 38) and CS (N = 37) revealed significantly higher levels of ferritin (P = .004), and resistin (P = .03) and lower level of leptin (P = .03) among FEP patients group. Seven months of antipsychotic drug treatment in patients (N = 36) ameliorated clinical symptoms, but increased significantly body mass index (BMI; P = .002) and these changes were accompanied by increased levels of C-peptide (P = .03) and leptin (P = .02), as well as decreased level of adiponectin (P = .01). Conclusions Seven months of antipsychotic drug treatment suppressed the clinical symptoms of psychosis whereas caused imbalance in metabolic biomarkers and increased BMI. These findings provide insight into antipsychotic-induced MetS and refer to problems in insulin processing already present in the early stage of the chronic psychotic disorder.
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