期刊
ACS APPLIED BIO MATERIALS
卷 2, 期 1, 页码 454-463出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00650
关键词
shape memory polyurethanes; oxidative degradation; resorbable polymers; porous scaffold
资金
- NASA Harriett G. Jenkins Fellowship [NNX15AU29H]
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [U01-NS089692]
- NASA [NNX15AU29H, 802916] Funding Source: Federal RePORTER
Minimally invasive medical devices are of great interest, with shape memory polymers (SMPs) representing one such possibility for producing these devices. Previous work with low density, highly porous SMPs has demonstrated oxidative degradation, while attempts to incorporate hydrolytic degradation have resulted in rapidly decreasing glass transition temperature (T-g), ultimately preventing strain fixity of the materials at clinically relevant temperatures. Through esterification of the amino alcohol triethanolamine, an alcohol containing network was synthesized and incorporated into SMPs. These ester networks were used to control the bulk morphology of the SMP, with the T-g remaining above 37 degrees C when 50% of the alcohol was contributed by the ester network. This methodology also yielded SMPs that could degrade through both hydrolysis and oxidation; by oxidation, the SMPs degrade at a similar rate as the control materials (0.2%/day mass) for the first 30 days, at which point the rate changes to 3.5%/day until the samples become too fragile to examine at 80 days. By comparison, control materials have lost approximately 30% of mass by 140 days, at a constant rate of degradation, demonstrating that the ester SMPs are a promising material system for producing more rapidly degradable, soft, porous biomaterials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据