期刊
NANOSCALE
卷 11, 期 2, 页码 706-716出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr08109c
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资金
- National Key Research and Development Program of China [2016YFB0700800]
- Intergovernmental Cooperation in Science and Technology [2016YFE0125300]
- NSFC [81172182, 81671829]
- fund of Key Laboratory of Advanced Materials of Ministry of Education [2017AML12]
Nano-photothermal therapy (NPTT) has attracted increasing interest recently due to its high efficiency, excellent selectivity and non-ionizing radiation damage. Despite a tremendous amount of exciting pre-clinical results reported in the past few years, however, the further clinic application of NPTT is still difficult. To combine NPTT with clinical surgery more closely, novel multifunctional optical-magnetic nanosystems have been synthesized and applied for preoperative NPTT to assist in the follow-up surgery, termed neoadjuvant NPTT. Remarkably, nanoparticles are mainly aggregated in the cytoplasm of tumor cells in vitro and largely accumulated in the tumor in vivo 24 h after injection. Under the guidance of tri-modality imaging, preoperative NPTT could shrink the tumor in a short time and make the boundary between the tumor and surrounding normal tissues clearer, which is conducive to subsequent surgery resection. Furthermore, the 50% survival rate is up to 50 days compared with 35 days for standard surgery, 31 days for PTT alone and 24 days for non-surgery groups. Therefore, NPTT can effectively assist in surgery used before operation. This study provides a new idea for the clinical transformation of NPTT in the future.
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