期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 4, 页码 478-481出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc08943d
关键词
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资金
- National Natural Science Foundation of China [21601124, 21671135, 21701111]
- Shanghai Sailing Program [17YF1413700]
- Ministry of Education of China [PCSIRT_IRT_16R49]
- International Joint Laboratory on Resource Chemistry (IJLRC)
A small Fe3O4 nanoparticles-based T-1 contrast agent was assembled into a pH- and glutathione-responsive T-2-T-1 switching contrast agent, Fe3O4-ZIF-8. In vivo T-1-weighted images of mice showed that Fe3O4-ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.
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