期刊
MOLECULAR MEDICINE REPORTS
卷 16, 期 6, 页码 9573-9578出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2017.7793
关键词
1-tetradecanol; Helicobacter pylori; IL-8; vascular endothelial growth factor; gastric epithelial cells
资金
- National Research Foundation of Korea (NRF) in the Ministry of Science, ICT, and Future Planning of Korea (MSIP) [NRF-2015R1A2A2A01002360]
Helicobacter pylori (H. pylori) infection activates pro-inflammatory mediators, including interleukin (IL) -8 and vascular endothelial growth factor (VEGF) in gastric epithelial cells. 1-Tetradecanol (1-TD) has been purified from Dendropanax morbifera Leveille; its physiological activities are poorly understood. The present study assessed whether 1-TD has an effect on H. pylori-mediated inflammation in AGS gastric epithelial cells. 1-TD reduced IL-8 production by AGS cells in response to H. pylori in a significant and dose-dependent manner, as measured by ELISA. Western blot analysis demonstrated that 1-TD also suppressed the activation of nuclear factor-kappa B, and two mitogen activated protein kinase species (p38 and extracellular signal-regulated kinase 1/2), but not c-Jun N-terminal kinase in H. pylori-infected AGS cells. As predicted, VEGF expression and hypoxia inducible factor-1 alpha stabilization induced by H. pylori in AGS cells were inhibited by 1-TD. In addition, 1-TD directly inhibited the growth of H. pylori in a dose-dependent manner, as investigated by measuring the optical density. These findings indicated that 1-TD may be a potential preventive or therapeutic agent for H. pylori-induced gastric inflammation.
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