4.5 Article

Screening and validation of serum protein biomarkers for early postmenopausal osteoporosis diagnosis

期刊

MOLECULAR MEDICINE REPORTS
卷 16, 期 6, 页码 8427-8433

出版社

SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2017.7620

关键词

osteoporosis; serum biomarker; Fractalkine; tissue inhibitor of metalloproteinases-1; monocyte chemotactic protein-1

资金

  1. National Natural Science Foundation of China [81572192]
  2. Natural Science Foundation of Shannxi Province [606308942,029]

向作者/读者索取更多资源

Postmenopausal osteoporosis is one of the most prominent worldwide public health problems and the morbidity is increasing with the aging population. It has been demonstrated that early diagnosis and intervention delay the disease progression and improve the outcome. Therefore, searching for biomarkers that are able to identify postmenopausal women at high risk for developing osteoporosis is an effective way to improve the quality of life of patients, and alleviate social and economic burdens. In the present study, a protein array was used to identify potential biomarkers. The bone mineral densities of 10 rats were dynamically measured in an ovariectomized model by micro-computed tomography assessment, and the early stage of osteoporosis was defined. Through the protein array-based screening, the expression levels of six serum protein biomarkers in ovariectomized rats were observed to alter at the initiation stage of the postmenopausal osteoporosis. Fractalkine, tissue inhibitor of metalloproteinases-1 and monocyte chemotactic protein-1 were finally demonstrated to be increased in the serum of eight enrolled postmenopausal osteoporosis patients using ELISA assay and were correlated with the severity of progressive bone loss. These biomarkers may be explored as potential early biomarkers to readily evaluate and diagnose postmenopausal osteoporosis in the clinic.

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