期刊
MOLECULAR MEDICINE REPORTS
卷 16, 期 6, 页码 8069-8075出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2017.7591
关键词
miR-372; E2F1; breast cancer; proliferation; apoptosis
资金
- Foundation of Science and Technology Bureau of Wenzhou [Y20100257, Y20160403]
- Foundation of Traditional Chinese Medicine of Zhejiang Province [2009C520014]
- Foundation of Public Welfare Technology Application of Zhejiang Province [2015C33100]
Breast cancer is the most prevalent cancer and the leading cause of cancer-associated mortalities among women worldwide today. Accumulating evidence suggested that miR-372 may serve important roles in the initiation and development of various human cancers. However, the role of miR-372 in breast cancer remains unknown. The present study demonstrated that the expression level of miR-372 in human breast cancer tissues and cell lines is significantly reduced compared with normal breast tissues cell lines. Furthermore, results of functional assays indicated that miR-372 inhibits cell proliferation and induces apoptosis in the MCF-7 human breast cancer cell line. E2F1 was identified as a direct functional target of miR-372 in breast cancer. In conclusion, the findings revealed that miR-372 may have the potential to act as a novel molecule for the diagnosis and therapy of patients with breast cancer.
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