期刊
JOURNAL OF APPLIED GERONTOLOGY
卷 38, 期 2, 页码 277-289出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0733464817690679
关键词
Alzheimer's disease; older adults; naturalistic methodology; driving
类别
资金
- Washington University (University Research Strategic Alliance [URSA] 2016)
- National Institute on Aging [R01-AG043434, R01-AG43434-03S1, P50-AG05681, P01-AG03991, P01-AG026276]
- Charles and Joanne Knight Alzheimer's Research Initiative of the Washington University Knight Alzheimer's Disease Research Center
- Washington University Institute of Clinical and Translational Sciences (National Center for Advancing Translational Sciences [NCATS]) [UL1 TR000448]
- Washington University Institute of Clinical and Translational Sciences (NCATS of the National Institutes of Health [NIH]) [UL1 TR000448]
- NIH [5P30NS048056]
A clinical consequence of symptomatic Alzheimer's disease (AD) is impaired driving performance. However, decline in driving performance may begin in the preclinical stage of AD. We used a naturalistic driving methodology to examine differences in driving behavior over one year in a small sample of cognitively normal older adults with (n = 10) and without (n = 10) preclinical AD. As expected with a small sample size, there were no statistically significant differences between the two groups, but older adults with preclinical AD drove less often, were less likely to drive at night, and had fewer aggressive behaviors such as hard braking, speeding, and sudden acceleration. The sample size required to power a larger study to determine differences was calculated.
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