4.7 Article

Discovery, absolute assignments, and total synthesis of asperversiamides A-C and their potent activity against Mycobacterium marinum

期刊

CHEMICAL COMMUNICATIONS
卷 55, 期 8, 页码 1104-1107

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc09347d

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资金

  1. Syngenta
  2. Program of National Natural Science Foundation of China [U1706210, 41776141, 41606172, U1606403]
  3. Program of Natural Science Foundation of Shandong Province of China [JQ201510]
  4. Fundamental Research Funds for the Central Universities [201841004]
  5. Taishan Scholars Program, China
  6. China Postdoctoral Science Foundation [2017M622285]
  7. Qingdao Postdoctoral Researcher Applied Research Project, China

向作者/读者索取更多资源

Integrating molecular networking and H-1 NMR techniques successfully enabled the discovery of three new cycloheptapeptides, asperversiamides A-C (1-3). Their complete structures were further confirmed by total synthesis. All three compounds exhibited potent inhibitory activity against Mycobacterium marinum.

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