期刊
JOURNAL OF BIOMEDICAL SCIENCE
卷 26, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12929-019-0500-6
关键词
Cancer metastasis; microRNA; Extracellular vesicle; Microenvironment
资金
- Practical Research for Innovative Cancer Control [18ck0106366h0002]
- Japan Agency for Medical Research and Development, AMED
Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast cells, immune cells, and endothelial cells, to create a cancer microenvironment for their progression. Extracellular vesicles (EVs) are small vesicles that can be secreted by most types of cells and play an important role in cell-to-cell communications via transferring bioactive cargos, including variable RNAs, such as microRNAs (miRNAs), to recipient cells. miRNAs are a class of small noncoding RNAs that posttranscriptionally regulate gene expression. The transfer of them to recipient cells influences the metastatic process of primary tumors. In this review, we summarize the function of miRNAs packaged in EVs in cancer metastasis and discuss the clinical utility of miRNAs in EVs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据