Dipeptidyl peptidase-4 inhibitors: Anti-diabetic drugs with potential effects on cancer

Dipeptidyl peptidase (DPP-4) inhibitors belong to the oral antidiabetic drugs. They are used for the treatment of Type 2 Diabetes mellitus. DPP-4 is an enzyme which puts down the action of hormone, incretin. Incretins belong to the group of hypoglycaemic gastrointestinal hormones. Some studies show that DPP-4 inhibitors causes cancer and some study show that they have anticancer property. This review sheds light on the role of the different types of DPP-4 inhibitors in cancer therapy. (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.