期刊
MOLECULAR IMMUNOLOGY
卷 90, 期 -, 页码 50-56出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2017.07.004
关键词
Cancer; Chemokines; Inflammation; Tumour immunology; Stem cells
资金
- China Postdoctoral Science Foundation Funded Project [2016M600383]
- Special Funded Projects of National Postdoctoral Fund [2017T100337]
- project of science and technology development research center of ministry of health [28-10-2]
- Natural Science Foundation of Shandong Province [ZR2010HL038]
- Jining Municipal Science and Technology development projects [2012jnjc16, 2014jnnk23]
- Shandong provincial medical and health science and technology development project [2013WS033]
- Shandong Province Traditional Chinese medicine science and technology development project [2015-244]
- Project of Shandong Province Higher Educational Science and Technology Program [J15LL11]
The interleukin (IL)-17 superfamily, a relatively new family of cytokines, consists of six ligands (from IL-17A to IL-17F), which bind to five receptor subtypes (fromIL-17RA toIL-17RE) and induce downstream signaling. IL-17A, a prototype member of this family, has been reported to be involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. Unlike IL-17A, which is mainly produced by T helper 17 cells, IL-17B is widely expressed in various tissues. Recently, the biological function of IL-17B in diseases, particularly tumors, has attracted the attention of researchers. We previously reported that the expression ofIL-17RB increased in gastric cancer tissues and demonstrated that IL-17B/IL-17RB signaling plays a critical role in gastric tumor progression. However, studies on IL-17B are scant. In this review, we detail the structural characteristics, expression patterns, and biological activities of IL-17B and its potential role in the pathogenesis of diseases.
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