期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 49, 期 1, 页码 376-382出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-018-3721-8
关键词
Risk factor; Opioid; ASD; Developmental disorder; Pregnancy
资金
- Centers for Disease Control and Prevention (CDC) [U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, U10DD000498]
- Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health [T32HD007489, U54 HD090256]
Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child's risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.
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