期刊
MOLECULAR DIVERSITY
卷 21, 期 4, 页码 957-966出版社
SPRINGER
DOI: 10.1007/s11030-017-9768-1
关键词
Triazene; Chalcone; Glycosides; Synthesis; Antiproliferative activity
类别
资金
- Natural Science Foundation of China [J1210060]
- Science and Technology Planning Project of Henan Province [0624420031]
- Basic Research Development Program of Henan Province [022463001]
By combining triazenes with chalcones, we designed and synthesized 12 novel glycosides. The antiproliferative activity of all products was screened using an MTT assay against MGC803 cells and PC-3 cells. Compound 2b(6) displayed more potent antiproliferative activity than dacarbazine. Furthermore, we explored the preliminary structure activity relationship of all target compounds. The derivatives in this work might serve as bioactive fragments and lead compounds for developing more potent cytotoxic agents.
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